Direct access to novel chromeno-pyrimidine-N-oxides via tandem base catalyzed double nucleophilic addition/dehydration reaction

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• 作者：Venkata Prasad Jalli^a ; Satyanarayana Reddy Jaggavarapu^a ; Anand Solomon Kamalakaran^a ; Sravan Kumar Gangisetty^a ; Jagadeesh Babu Nanubolu^b ; Gopikrishna Gaddamanugu^a ; ^{gkrishnagps@gmail.com}
• 关键词：QZCPVWRHWLGZJD-UHFFFAOYSA-N ; HGNLWCXQPBEHAT-UHFFFAOYSA-N ; VOBIWWJGFIAUIV-UHFFFAOYSA-N ; PNWBUKZJKURDMT-UHFFFAOYSA-N ; CMKJZGPYCAVWNQ-UHFFFAOYSA-N ; DWAXYOOGBGLLFQ-UHFFFAOYSA-N ; HYXZZOMBGDHTDV-UHFFFAOYSA-N ; NVQPPAPJMRXZDO-UHFFFAOYSA-N ; VFRJMQRLQOWGFJ-UHFFFAOY
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：13 March, 2013
• 年：2013
• 卷：54
• 期：11
• 页码：1491-1494
• 全文大小：1027 K

文摘

A facile protocol for direct access to chromeno-pyrimidine-N-oxides is reported by the reaction of 4-chloro-3-formylcoumarin and aromatic carboximide oximes via tandem double nucleophilic addition and dehydration reactions. The one-pot reaction serves as an alternative protocol for achieving regioselective pyrimidine mono-N-oxide products as pure precipitates in good to excellent yields. The structure of the product was confirmed by X-ray analysis.