Activation of unfolded protein response pathway during infectious salmon anemia virus (ISAV) infection in聽vitro an in聽vivo
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- 作者：Arturas Kavaliauskis arturas.kavaliauskis@farmasi.uio.no" class="auth_mail" title="E-mail the corresponding author ; Marianne Arnemo marianne.arnemo@farmasi.uio.no" class="auth_mail" title="E-mail the corresponding author ; Anne-Lise Rishovd a.l.rishovd@farmasi.uio.no" class="auth_mail" title="E-mail the corresponding author ; Tor Gjø ; en ; tor.gjoen@farmasi.uio.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER stress ; Unfolded protein response ; Microbial stress response ; ISAV ; Salmon ; Innate immunity
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：54
- 期：1
- 页码：46-54
- 全文大小：2225 K
文摘
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Infectious salmon anemia virus induce morphological changes indicating unfolded protein response (UPR) in salmon cells.
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UPR induced by infectious salmon anemia virus display important differences from classical UPR induced by drugs.
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Despite the increased eIF2a phosphorylation ISAV infection does not attenuate the synthesis of interferon and ISGs.