No Differences in Symptom Burden Between Colorectal Cancer Patients Receiving Curative Versus Palliative Chemotherapy

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• 作者：Kari Rø ; hrl ; RN ; MPH^a ; ^b ; ^{kari.rohrl@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author} ; Marianne Grø ; nlie Guren ; MD ; PhD^b ; ^c ; Christine Miaskowski ; RN ; PhD^e ; Bruce A. Cooper ; PhD^e ; Lien My Diep ; MSc^f ; Tone Rustø ; en ; RN ; PhD^a ; ^d
• 关键词：Multiple symptoms ; colorectal cancer ; adjuvant chemotherapy ; palliative chemotherapy ; symptom burden ; symptom distress
• 刊名：Journal of Pain and Symptom Management
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：52
• 期：4
• 页码：539-547
• 全文大小：166 K

文摘

Colorectal cancer (CRC) is one of the most common cancers worldwide. Patients with CRC may have multiple cooccurring symptoms as a result of their disease or its treatment. Little is known about potential differences in symptom burden in CRC patients scheduled to receive curative versus palliative chemotherapy (CTX).

Objectives

The purposes of this study were to investigate the overall symptom burden of patients with CRC before their first CTX treatment or before the initiation of a new CTX regimen and to evaluate for differences in symptom occurrence, severity, and distress between patients with CRC who were scheduled to receive curative versus palliative CTX.

Methods

Consecutive patients with CRC were recruited (n = 120), and symptoms were assessed using the Memorial Symptom Assessment Scale before the initiation of the CTX. The most common symptoms that occurred in ≥30% of the patients were evaluated. Differences in occurrence rates and severity and distress scores between the curative (n = 68) and palliative (n = 52) patient groups were evaluated using binary logistic regression and ordinal logistic regression analyses, respectively.

Results

In both groups, patients reported an average of 10 cooccurring symptoms. Worrying (65%), lack of energy (59%), feeling drowsy (54%), feeling bloated (53%), pain (51%), and difficulty sleeping (50%) were the most prevalent symptoms. Problems with sexual interest had the highest severity and distress scores in both groups. For the 13 most common symptoms, no significant differences were found between the two patient groups on any of the Memorial Symptom Assessment Scale dimensions (i.e., occurrence, severity, distress).

Conclusion

Regardless of the reason for CTX, CRC patients experience a large number of cooccurring symptoms.