Role of respiratory-gated PET/CT for pancreatic tumors: A preliminary result

详细信息    查看全文

• 作者：Takeo Kasuya^a ; ¹ ; ^{kasumakidon@yahoo.co.jp} ; Ukihide Tateishi^a ; ^{utateish@yokohama-cu.ac.jp} ; Kazufumi Suzuki^b ; ² ; ^{kazufumi@dokkyomed.ac.jp} ; Hiromitsu Daisaki^c ; ³ ; ^{hdaisaki@gmail.com} ; Yuji Nishiyama^a ; ¹ ; ^{t116052g@yokohama-cu.ac.jp} ; Masaharu Hata^a ; ¹ ; ^{hatahata@yokohama-cu.ac.jp} ; Tomio Inoue^a ; ¹ ; ^{sec229@yokohama-cu.ac.jp}
• 关键词：PET/CT ; Respiratory-gated PET/CT ; Pancreatic cancer
• 刊名：European Journal of Radiology
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：82
• 期：1
• 页码：69-74
• 全文大小：569 K

文摘

Purpose

The aim of this study is to ascertain role of respiratory-gated PET/CT for accurate diagnosis of pancreatic tumors.

Materials and methods

Prior to clinical study, the phantom study was performed to evaluate the impact of respiratory motion on lesion quantification. Twenty-two patients (mean age 65 years) with pancreatic tumors were enrolled. Pathological diagnoses by surgical specimens consisted of pancreatic cancer (n = 15) and benign intraductal papillary mucinous neoplasm (IPMN, n = 7). Whole-body scan of non-respiratory-gated PET/CT was performed at first, and subsequent respiratory-gated PET/CT for one bed position was performed. All PET/CT studies were performed prior to surgery. The SUV max obtained by non-respiratory-gated PET/CT and respiratory-gated PET/CT, and percent difference in SUVmax ( % SUVmax) were compared.

Results

The profile curve of 5 respiratory bin image was most similar to that of static image. The third bin of 5 respiratory bin image showed highest FWHM (24.0 mm) and FWTM (32.7 mm). The mean SUVmax of pancreatic cancer was similar to that of benign IPMN on non-respiratory-gated PET/CT (p = 0.05), whereas significant difference was found between two groups on respiratory-gated PET/CT (p = 0.016). The mean % SUV of pancreatic cancer was greater than that of benign IPMN (p < 0.0001). Identification of the primary tumor in pancreatic head (n = 13, 59 % ) was improved by using respiratory-gated PET/CT because of minimal affection of physiological accumulation in duodenum.

Conclusion

Respiratory-gated PET/CT is a feasible technique for evaluation of pancreatic tumors and allows more accurate identification of pancreatic tumors compared with non-respiratory-gated PET/CT.