Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation
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- 作者：Akira Takashimaa ; Daiju Fukudaa ; daiju.fukuda@tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kimie Tanakab ; Yasutomi Higashikunic ; Yoichiro Hiratad ; Sachiko Nishimotoe ; Shusuke Yagia ; Hirotsugu Yamadaa ; Takeshi Soekia ; Tetsuzo Wakatsukia ; Yutaka Taketanif ; Michio Shimabukurog ; Masataka Sataa
- 关键词：Atherosclerosis ; Inflammation ; Lipid raft ; Macrophage ; n-3 poly unsaturated fatty acid ; Toll-like receptor 4
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：142-150
- 全文大小：1650 K
文摘
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n-3 PUFAs inhibited the development of atherosclerosis in Apoe−/− mice fed a western-type diet.
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DHA had additional anti-atherosclerotic effects when combined with EPA in Apoe−/− mice.
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DHA attenuated pro-inflammatory activation of macrophages by inhibiting TLR4 accumulation into lipid rafts.