HLA-G coding region and 3′untranslated region (3′UTR) in two Chinese Han populations
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- 作者：Wen Yi Wanga ; Wei Tiana ; b ; tianwei6@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; tianwei3@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Xue Xiang Liua ; Li Xin Lib
- 关键词：Sequence-based typing ; Linkage disequilibrium ; 3&rsquo ; Untranslated region ; Chinese Han population ; HLA-G
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：176
- 期：Complete
- 页码：65-71
- 全文大小：543 K
文摘
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A PCR-SBT protocol combined with cloning was used in this study, resolving ambiguity derived from different algorithms for HLA-G genotype imputation.
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Three HLA-G alleles in the coding region, 4 polymorphic sites in the 3′UTR, 3 3′UTR haplotypes and 4 HLA-G EHs differed significantly in their distributions between the two representative Chinese Han populations (all P ≤ 0.0001).
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There was evidence for balancing selection acting on HLA-G 3′UTR positions +3010, +3142 and +3187 in the two populations, emphasizing the importance of these positions in the regulation of HLA-G expression.