Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
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- 作者：Zhong-Ze Fanga ; b ; c ; Dunfang Zhangd ; Yun-Feng Caoc ; Cen Xiea ; Dan Lue ; Dong-Xue Suna ; Naoki Tanakaa ; Changtao Jianga ; Qianming Chend ; Yu Chend ; Haina Wangf ; Frank J. Gonzaleza ; gonzalef@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：CA ; cholic acid ; CDCA ; chenodeoxycholic acid ; CPT-11 ; Irinotecan ; DCA ; deoxycholic acid ; HDCA ; hydroxyursodeoxycholic acid ; IL-10 ; interleukin-10 ; MCA ; muricholic acid ; α-MCA ; α-muricholic acid ; β-MCA ; β-muricholic acid ; ω-MCA ; ω-muricholic acid ; T-α-MCA ; tauro-α-muricholic acid ; T-β-MCA ; tauro-β-muricholic acid ; TUDCA ; tauro-ursodeoxycholic acid ; THDCA ; tauro-hydroxyursodeoxycholic acid ; T ; tauro-chenodeoxycholic acid ; TDCA ; tauro-deoxycholic acid ; TCA ; tauro-cholic acid ; TCT ; T cell receptor
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：291
- 期：Complete
- 页码：21-27
- 全文大小：1271 K
文摘
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CPT-11 is an effective anticancer drug, but induced toxicity limits its application in the clinic.
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CPT-11 decreased IL-10-producing CD4 T cell frequency in intestinal lamina propria lymphocytes.
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CPT-11 altered the composition of bile acid metabolites, notably DCA and TDCA in liver, bile and intestine.
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DCA and TDCA potentiated CPT-11-induced suppression of IL-10 secretion by active CD4+ naive T cells.