Practical Considerations in Managing Relapsed Multiple Myeloma

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• 作者：Amit Agarwal¹ ; Eric Chow² ; Manisha Bhutani² ; Peter M. Voorhees² ; Reed Friend² ; Saad Z. Usmani² ; ^{saad.usmani@carolinashealthcare.org}
• 关键词：Carfilzomib ; Daratumumab ; Elotuzumab ; Pomalidomide ; Refractory ; Treatment ; Transplant
• 刊名：Clinical Lymphoma Myeloma and Leukemia
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：17
• 期：2
• 页码：69-77
• 全文大小：318 K
• 卷排序：17

文摘

Considerable advances have been made in the treatment of relapsed and relapsed/refractory multiple myeloma, with numerous novel agents and combination strategies receiving regulatory approval worldwide during the past several years. An increasing body of phase III data has clearly demonstrated increased overall response rates, improved depths of response, and more durable responses when a third novel agent is incorporated into lenalidomide-dexamethasone and bortezomib-dexamethasone platforms, in most cases with acceptable toxicity. The carfilzomib-dexamethasone doublet has also demonstrated promising activity. With this rapid progress has come many new questions. We review the data supporting the use of these novel treatment paradigms for relapsed/refractory multiple myeloma, discuss the place of autologous and allogeneic hematopoietic stem cell transplantation in this rapidly evolving treatment space, and propose strategies to best use these regimens, considering the disease, host, and previous treatment factors.