Computational study of the possible formation of the ternary complex between thrombin, antithrombin III and fucosylated chondroitin sulfates

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• 作者：Alexey G. Gerbst ; Nadezhda E. Ustyuzhanina ; Nikolay E. Nifantiev ; ^{nen@ioc.ac.ru" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Mendeleev Communications
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：25
• 期：6
• 页码：420-421
• 全文大小：448 K

文摘

Computer docking studies suggest an explanation for better anticoagulant activity of fucosylated chondroitin sulfates as compared to non-fucosylated ones due to the formation of the ternary complex with thrombin and antithrombin III.