Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate
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- 作者：Rafal Janika ; Lynsie A.M. Thomasonb ; Andrew M. Stanisze ; Paul Forsythec ; e ; John Bienenstockd ; e ; Greg J. Stanisza ; b ; f ; stanisz@sri.utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microbiome ; Neurotransmitters ; GABA ; Glutamate ; NAA ; Magnetic resonance spectroscopy
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：988-995
- 全文大小：1165 K
文摘
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We have shown for the first time that the concentrations of certain metabolites increase in the brain following oral treatment with L. rhamnosus and do so with distinct kinetics.
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Both tNAA and Glx increased relatively early after the start of L. rhamnosus die, while GABA was only elevated at four weeks.
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These results suggest beneficial bacteria may alter brain function and offer translational approaches into the clinical setting.