Demonstrate advanced negative plasticity and remodeling in human retinitis pigmentosa (RP) prior to photoreceptor loss.

Alterations in both small molecule and protein signatures of neurons and glia.

Müller cells are the first cells to show metabolic stress in retina and the last cells left in degenerate retina.

Retinal network topologies are altered in RP.

Unless we understand the mechanisms of retinal degeneration, interventions designed to rescue vision loss will likely fail.