Leishmania major strains isolated from distinct endemic areas show diverse cytokine mRNA expression levels in C57BL/6 mice: Toward selecting an ideal strain for the vaccine studies
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- 作者：Sima Darabi ; Vahid Khaze ; Farhad Riazi-Rad ; Haiedeh Darabi ; Fariborz Bahrami ; Soheila Ajdary ; Mohammad Hossein Alimohammadian ; mhalimoh@pasteur.ac.ir" class="auth_mail" title="E-mail the corresponding author ; mhalimoham@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leishmania major ; Parasite burden ; Cytokine mRNA ; Real-time PCR ; C57BL/6 mice
- 刊名：Cytokine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：76
- 期：2
- 页码：303-308
- 全文大小：894 K
文摘
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Pathogenicity/parasite burden of 4 L. major strains were compared in C57BL/6 mice.
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The expressions of C57BL/6 cytokine gene induced by the 4 strains were evaluated.
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Strain DA39 showed higher expression of Ifng and Il12 at week 8 post-infection.
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The ratio of Ifng/Il4 mRNA expressions in DA39 was higher than the other strains.
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DA39 appears as a suitable strain for leishmaniases vaccine studies.