CXCL12/CXCR4/CXCR7 axis could act as a double-edged sword in the pathogenesis of MS.
CXCL12 may induce CNS inflammatory response by leukocyte migration.
Additionally, CXCL12 may contribute to remyelination and neuroprotection in MS.
Potential therapeutic strategies may include preservation of CXCL12 level or the use of inhibitors.