Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice
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- 作者：Má ; rcia Calheiros Chaves Silva<sup>asup> ; Caren Ná ; dia Soares de Sousa<sup>asup> ; Patrí ; cia Xavier Lima Gomes<sup>asup> ; Gersilene Valente de Oliveira<sup>asup> ; Fernanda Yvelize Ramos Araú ; jo<sup>asup> ; Naiara Coelho Ximenes<sup>asup> ; Jé ; ssica Calheiros da Silva<sup>asup> ; Germana Silva Vasconcelos<sup>asup> ; Luzia Kalyne Almeida Moreira Leal<sup>bsup> ; Danielle Macê ; do<sup>asup> ; Silvâ ; nia Maria Mendes Vasconcelos<sup>asup><sup> ; sup><sup>silvania_vasconcelos@yahoo.com.br" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：ALA ; alpha-lipoic acid ; CAT ; catalase ; CORT ; corticosterone ; DVS ; desvenlafaxine ; GSH ; reduced glutathione ; HC ; hippocampus ; LP ; lipid peroxidation ; MDA ; malondialdehyde ; MDD ; major depressive disorder ; PMD ; psychotic major depression ; PFC ; prefrontal cortex ; ROS ; reactive oxygen species ; SNRI ; serotonin and noradrenaline reuptake inhibitor ; SOD ; superoxide dismutase ; SSRI ; selective serotonin reuptake inhibitors ; ST ; striatum
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：142-148
- 全文大小：583 K
文摘
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A model of depression has been developed by chronic CORT administration in mice.
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ALA and DVS decreased oxidative stress in a CORT-induced depression model in mice.
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Antioxidant and antidepressant in association: a new therapeutic to depression