Are epidemiologic cut-off values predictors of the in vivo efficacy of azoles in experimental aspergillosis?

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• 作者：Enrique Calvo ; F. Javier Pastor ; Deanna A. Sutton ; Anette W. Fothergill ; Michael G. Rinaldi ; Valentina Salas ; Josep Guarro
• 关键词：Aspergillus ; Voriconazole ; Posaconazole ; Epidemiologic cutoff values ; Murine models
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：74
• 期：2
• 页码：158-165
• 全文大小：1116 K

文摘

We tried to correlate the in vitro activity and the in vivo efficacy of voriconazole (VRC) and posaconazole (POS) against Aspergillus flavus and Aspergillus niger. The in vitro susceptibility of a large set of isolates was determined by broth microdilution and disk diffusion methods, while the in vivo efficacy was assessed in a murine model of disseminated infection. For A. flavus, VRC showed efficacy even for strains with MICs above the epidemiologic cutoff value (ECV) (1 ¦Ìg/mL). For A. niger, VRC was ineffective against those strains for which the MIC was 1 dilution below the corresponding ECV (2 ¦Ìg/mL). POS showed efficacy against all the strains of both species included in the study, although isolates with MICs > ECV were not tested.