An acute, non-therapeutic dose of methylphenidate disrupts partner preference in female rats

详细信息    查看全文

• 作者：Alexa Gomez^a ; Alexandra N. Petrucci^a ; Lauren Dance^b ; Jessica Morales-Valenzuela^a ; Nicole Gibbs^a ; Cara C. Dahlhausen^c ; Jessica R. Villatoro^c ; Russell F. Frohardt^c ; Fay A. Guarraci^a ; ^{guarracf@southwestern.edu}
• 关键词：Locomotion ; Sexual motivation ; Psychomotor stimulants ; Ritalin ; Sexual behavior ; Proceptive behaviors ; Open field
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：150-151
• 期：Complete
• 页码：100-107
• 全文大小：720 K
• 卷排序：150

文摘

A high, recreational dose of methylphenidate (MPH; 10.0 mg/kg i.p.) disrupts sexual behavior in female rats. Methylphenidate causes female rats to avoid the male stimulus during partner preference. The rate of proceptive behaviors (e.g., hops and darts) is reduced following MPH administration. Methylphenidate effects are equally robust in hormone-primed ovariectomized rats as in estrus female rats.