Long-term results of percutaneous balloon valvuloplasty of congenital aortic stenosis in adolescents and young adults

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• 作者：Neeraj Awasthy^a ; ^{n_awasthy@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Ria Garg^b ; S. Radhakrishnan^c ; Savitri Shrivastava^d
• 关键词：Balloon aortic valvotomy ; Balloon annulus ratio ; Aortic valve restenosis ; Aortic valve replacement ; Young adult
• 刊名：Indian Heart Journal
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：68
• 期：5
• 页码：604-611
• 全文大小：577 K

文摘

Balloon aortic valvuloplasty (BAV) is a well accepted modality of treatment in congenital aortic stenosis in all age groups. Although in infants and children it is the modality of choice, in adolescents and young adults, it is of debatable efficacy.

Aim

To evaluate long-term results of aortic valvuloplasty particularly in adolescent and adults (>12 years) and compare the outcome in other age groups that are <1 year and between 1 are 11 years.

Setting

Tertiary referral center.

Patients

165 consecutive patients treated at the median age of 9 years (1 day to 64 years). The follow-up was up to 14 years (median 3 years). The whole cohort was divided into 3 age-based subgroups: Group A (<1 year) m>nm> = 45, Group B (1 year–11 years) m>nm> = 52, and Group C (>12 years) m>nm> = 68. The characteristics of each subgroup were mutually compared.

Intervention

Percutaneous balloon valvuloplasty with mean (SD) balloon to annulus ratio of 0.93.

Main outcome measures were repeat BAV, significant aortic regurgitation (AR), and aortic valve replacement/repair.

Results

The incidence of significant AR from the whole cohort was 9.9% (8% moderate, 1.9% severe); m>nm> = 16. Group A = significant AR 9.5% (7.1% moderate, 2.4% severe), Group B = significant AR 11.3% (9.4% moderate, 1.9% severe), and Group C = significant AR 9% (7.5% moderate, 1.5% severe); m>pm> value = 0.99 (Group C vs Group A) and 0.92 (Group C vs Group B).

Repeat BAV rate was 13.3% (m>nm> = 22 out of 165 patients). Group A – m>nm> = 5 (11.9%), Group B – m>nm> = 10 (18.2%), and Group C – m>nm> = 7 (10.3%). m>pm> Value = 0.78 (C vs A) and 0.19 (C vs B).

Surgery in follow-up was needed in m>nm> = 4 (2.4%), none in Group A, 2 patients in Group B (3.6%), and 2 patients in group C (2.9%). Patients were followed up for a period of 14 years; Group A = up to 8 years, Group B = up to 13 years, and Group C = up to 14 years. Mean survival probability after the procedure was 8 years (Group A = 6.5 years, Group B = 8.1 years, and Group C = 9.9 years), and m>pm> value = 0.49 (A vs B), 0.23 (B vs C), and 0.4 (A vs C).

Conclusion

There is no statistical difference in the long-term outcome in the adults and adolescents as compared to the children; thus BAV remains an obvious treatment of choice with good long-term outcome.