Prevalence of glucose-6-phosphate dehydrogenase deficiency in India: An updated meta-analysis

详细信息    查看全文

• 作者：Pradeep Kumar ; Upendra Yadav ; Vandana Rai
• 关键词：G6PD deficiency ; Hemolytic anemia ; Meta-analysis ; Prevalence
• 刊名：Egyptian Journal of Medical Human Genetics
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：17
• 期：3
• 页码：295-302
• 全文大小：1307 K

文摘

Glucose-6-phosphate dehydrogenase (G6PD) is a house keeping enzyme which catalyzes the first step in the hexose monophosphate pathway of glucose metabolism. G6PD deficiency is the commonest hemolytic X-linked genetic disease, which affects approximately 400 million people worldwide. The prevalence rate of G6PD deficiency varies worldwide with a higher prevalence in malarial endemic population. In India several studies were published and reported with varying incidences of this disease in different populations.

Objective

The aim of the present study was to assess the overall frequency of G6PD deficiency in the Indian population using meta-analysis.

Methods

PubMed, Science Direct, Google Scholar and Springer Link databases were searched for studies that investigated G6PD deficiency in Indian population. If any author studied different sub-populations we treated the study as an independent study.

Results

A total of 72 studies with a total sample size of 38,565 and 2,623 G6PD deficient subjects were included in the present meta-analysis. Meta-analysis was performed in both fixed and random effect models. Meta-analysis with random model showed an overall prevalence proportion as 0.085 (95% CI = 0.070–0.103; p = 0.000; tau = 0.826; I² = 0.486; Cochran Q = 0.999).

Conclusion

In conclusion the present meta-analysis confirms the overall magnitude of the frequency of G6PD deficiency (8.5%) in the Indian population.