Sulforaphane activates the cerebral vascular Nrf2-ARE pathway and suppresses inflammation to attenuate cerebral vasospasm in rat with subarachnoid hemorrhage
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- 作者：Xudong Zhaoa ; Liting Wenb ; Min Donga ; Xiaojie Lua ; luxiaojie1966@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARE ; antioxidant response element ; CVS ; Cerebral vasospasm ; NQO1 ; NAD(P)H ; quinone oxidoreductase-1 ; Nrf2 ; nuclear factor erythroid 2-related factor 2 ; RT-PCR ; reverse transcription-polymerase chain reaction ; SAH ; subarachnoid hemorrhage ; SFN ; sulforaphane ; HO-1 ; heme oxygenase-1
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：1653
- 期：Complete
- 页码：1-7
- 全文大小：860 K
文摘
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Nrf2–ARE signaling pathway was activated in the basilar artery after SAH.
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Sulforaphane enhanced the activity of Nrf2–ARE pathway in the basilar artery after SAH.
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Sulforaphane suppressed the inflammation in the CSF after SAH.
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Sulforaphane attenuated cerebral vasospasm after SAH may involve the Nrf2–ARE pathway.