Venomics of Calloselasma rhodostoma, the Malayan pit viper: A complex toxin arsenal unraveled
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- 作者：Esther Lai Har Tanga ; Choo Hock Tanb ; tanchoohock@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shin Yee Funga ; Nget Hong Tana ; tanngethong@yahoo.com.sg" class="auth_mail" title="E-mail the corresponding author
- 关键词：Calloselasma rhodostoma ; Malayan pit viper ; Venom proteome ; Venomics ; LC-MS/MS ; Coagulopathy
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：44-56
- 全文大小：791 K
文摘
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This venomic study unveils the proteome of Calloselasma rhodostoma venom (CRV).
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29 basic and 67 acidic proteins in 11 toxin families were identified in CRV.
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Snake venom metalloproteinases dominate by 41.17% of total venom proteins.
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This is followed by snaclecs (26%) and serine proteases including ancrod (15%).
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Complex hemotoxin isoforms and subunits have implication on antivenom production.