Co-delivery of docetaxel and verapamil by reduction-sensitive PEG-PLGA-SS-DTX conjugate micelles to reverse the multi-drug resistance of breast cancer

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• 作者：Yuanyuan Guo^a ; ^b ; Wenxiu He^a ; Shengfeng Yang^c ; Dujuan Zhao^a ; Zhonghao Li^d ; Yuxia Luan^a ; ^{yuxialuan@sdu.edu.cn}
• 关键词：PP-SS-DTX ; Reduction sensitive ; DTX ; VRP ; MDR ; Co-delivery
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：119-127
• 全文大小：2048 K
• 卷排序：151

文摘

The micelles showed sustained, reduction sensitive and programmed release profile. The micelles could completely restrain the efflux activity of p-gp and reverse MDR. The micelles prolonged the in vivo circulation and enhanced the drug accumulation.