Discovery of novel (1S)-(?)-verbenone derivatives with anti-oxidant and anti-ischemic effects

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• 作者：Chung Ju ; Sumi Song ; Sunyoung Hwang ; Chorong Kim ; Minkyoung Kim ; Jail Gu ; Yu-Kyoung Oh ; Kyeong Lee ; Jinsun Kwon ; Kiho Lee ; Won-Ki Kim ; Yongseok Choi
• 关键词：Cerebral ischemia ; Anti-oxidant activity ; Anti-excitotoxic activity ; Anti-ischemic activity ; Verbenone
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：1 October, 2013
• 年：2013
• 卷：23
• 期：19
• 页码：5421-5425
• 全文大小：900 K

文摘

A series of novel (1S)-(?)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-d-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-d-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.