Key advances in mechanisms of asthma, allergy, and immunology in 2009
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- 作者：Fred D. Finkelman ; Joshua A. Boyce ; Donata Vercelli ; Marc E. Rothenberg
- 关键词：Allergic conjunctivitis ; allergic inflammation ; anaphylaxis ; asthma ; asthma genetics ; atopic dermatitis ; eosinophils ; food allergy ; immediate hypersensitivity ; mast cells ; nasal polyposis ; polymorphisms
- 刊名：Journal of Allergy and Clinical Immunology
- 出版年：2010
- 出版时间：February 2010
- 年：2010
- 卷：125
- 期：2
- 页码：312-318
- 全文大小：126 K
文摘
The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis; and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential effect on human atopic disorders are summarized here.