- 作者：Sneha Panchal ; Ramtej J. Verma<sup> ; sup><sup>ramtejverma2000@yahoo.com" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Diethanolamine ; Curcumin ; Testosterone ; Steroidogenesis
- 刊名：Asian Pacific Journal of Reproduction
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：5
- 期：2
- 页码：128-131
- 全文大小：226 K
sSec_2">Methods
spara0015">Adult Swiss strain male albino mice were orally administered with diethanolamine (110, 165 and 330 mg/kg body weight) for 45 days. In another set of experiment, male albino mice were orally administered with curcumin (10, 25 and 50 mg/kg body weight) along with diethanolamine (330 mg/kg body weight) for 45 days. On completion of treatment, animals were humanely sacrificed, testis dissected out, blotted free of blood and used for biochemical analysis. The obtained serum samples were analyzed for serum testosterone level.
sSec_3">Results
spara0020">Diethanolamine caused significant (P < 0.05), dose-dependent reduction in total lipid and cholesterol contents, activities of 3β- and 17β-hydroxysteroid dehydrogenases in testis as well as significant reduction in serum testosterone level. However, co-treatment of curcumin along with diethanolamine caused significant (P < 0.05) dose-dependent amelioration in diethanolamine-induced changes in total lipid and cholesterol contents, activities of 3β- and 17β-hydroxysteroid dehydrogenases and serum testosterone levels.
sSec_4">Conclusions
spara0025">The results of the present study showed that curcumin significantly ameliorates diethanolamine reduced testicular steroidogenesis.