Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells

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• 作者：Kö ; lln ; Johanna ; Matzas ; Mark ; Jä ; nner ; Nathalie ; Mix ; Thorsten ; Klensang ; Katrin ; et. al.
• 关键词：hC3 ; human C3 ; CVF ; Cobra Venom Factor ; rCVF ; recombinant CVF ; nCVF ; native CVF ; scFv ; single chain fragment variable ; CHO ; Chinese hamster ovary ; GVBS⁺⁺ ; veronal buffered saline with gelantine ; MgCl₂ and CaCl₂ ; CDR ; compl
• 刊名：Molecular Immunology
• 出版年：2004
• 出版时间：May, 2004
• 年：2004
• 卷：41
• 期：1
• 页码：19-28
• 全文大小：374 K

文摘

The complement activating venom component Cobra Venom Factor (CVF), a functional and structural homologue of the human complement component C3, forms a stable CVF-dependent C3 convertase complex, which, in contrast to C3-dependent convertase effects continuous activation of the complement and, thereby, decomplementation.