Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography-tandem mass spectrometry
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- 作者：Fleur Gaudettea ; André ; a Sirhan-Daneaua ; b ; Maude St-Ongea ; b ; Jacques Turgeona ; b ; Veronique Michauda ; b ; v.michaud@umontreal.ca" class="auth_mail" title="E-mail the corresponding author ; veronique.michaud.chum@ssss.gouv.qc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oxycodone ; Noroxycodone ; Oxymorphone ; Mass spectrometry ; Liquid chromatography ; Plasma ; Human
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：1008
- 期：Complete
- 页码：174-180
- 全文大小：1152 K
文摘
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Our HPLC–MS/MS assay is accurate, robust and highly selective.
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The limit of detection of 30 pg/mL for all analytes.
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Analytical method suitable to conduct PK studies using a small single dose of OXY.
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Our assay permits a proper characterization of half-life.
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Our assay would determine precisely PK parameters in CYP2D6 EM and PM subpopulations.