The role of endosomes in innate and adaptive immunity
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- 作者：Paul A. Gleeson ; pgleeson@unimelb.edu.au" class="auth_mail
- 关键词：FACS ; fluorescence activated cell sorting ; MHCI ; MHC class I molecules ; MHCII ; MHC class II molecules ; APC ; antigen-presenting cells ; DC ; dendritic cells ; TCR ; T cell receptor ; MVB ; multi-vesicular body ; ILV ; intraluminal vesicles ; MARCH ; membrane-associated RING-CH ; ERAD ; ER-associated degradation ; NOX2 ; NADPH oxidase 2 ; TAP ; transporter associated with antigen processing ; MTOC ; microtubule organising centre ; ITAM ; tyrosine-based activation motifs ; unc119 ; Uncoordinated 119 ; BCR ; B cell antigen
- 刊名：Seminars in Cell and Developmental Biology
- 出版年：July 2014
- 年：2014
- 卷：31
- 期：Complete
- 页码：64-72
- 全文大小：1141 K
文摘
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Role of endosomal system is central to both innate and adaptive immune responses.
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Endosomes contribute to antigen presentation of MHCI, MHCII and CD1 molecules.
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Endosomes regulate antigen receptor signalling in both B cells and T cells.
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A number of immune receptors signal from intracellular endosomal compartments.
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The diverse roles of endosomes in a range of immune responses are discussed.