Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome
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- 作者：Raffaella Greco<sup>1sup> ; Lara Crucitti<sup>2sup> ; Maddalena Noviello<sup>3sup> ; Sara Racca<sup>4sup> ; Daniele Mannina<sup>1sup> ; Alessandra Forcina<sup>1sup> ; Francesca Lorentino<sup>1sup> ; Veronica Valtolina<sup>3sup> ; Serena Rolla<sup>4sup> ; Roee Dvir<sup>4sup> ; Mara Morelli<sup>1sup> ; Fabio Giglio<sup>1sup> ; Maria Chiara Barbanti<sup>1sup> ; Maria Teresa Lupo Stanghellini<sup>1sup> ; Chiara Oltolini<sup>5sup> ; Luca Vago<sup>1sup><sup> ; sup><sup>6sup> ; Paolo Scarpellini<sup>5sup> ; Andrea Assanelli<sup>1sup> ; Matteo G. Carrabba<sup>1sup> ; Sarah Marktel<sup>1sup> ; Massimo Bernardi<sup>1sup> ; Consuelo Corti<sup>1sup> ; Massimo Clementi<sup>4sup><sup> ; sup><sup>7sup> ; Jacopo Peccatori<sup>1sup> ; Chiara Bonini<sup>3sup> ; Fabio Ciceri<sup>1sup><sup> ; sup><sup>7sup><sup> ; sup><sup>ciceri.fabio@hsr.it" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Human herpesvirus 6 ; Allogeneic hematopoietic stem cell transplantation ; T cell immune reconstitution
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：22
- 期：12
- 页码：2250-2255
- 全文大小：722 K
文摘
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This work is a retrospective analysis of 54 adult patients, positive for human herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation.
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Viral encephalitis was reported for 10 patients.
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Mortality rate was relatively high in this population (1-year overall survival [OS], 38%).
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Better OS was associated with CD3<sup>+sup> cell count ≥200/µL at the time of HHV-6 reactivation.
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Prospective studies with characterization of HHV-6 immune responses are warranted.