Structure and Function of RNase AS, a Polyadenylate-Specific Exoribonuclease Affecting Mycobacterial Virulence In聽Vivo
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- 作者：Maria Romano1 ; 4 ; Robert van de Weerd2 ; 4 ; Femke C.C. Brouwer2 ; Giovanni N. Roviello1 ; Ruben Lacroix2 ; Marion Sparrius2 ; Gunny van den Brink-van Stempvoort2 ; Janneke J. Maaskant2 ; Astrid M. van der Sar2 ; Ben J. Appelmelk2 ; bj.appelmelk@vumc.nl" class="auth_mail ; Jeroen J. Geurtsen2 ; 3 ; 5 ; Rita Berisio1 ; 5 ; rita.berisio@cnr.it" class="auth_mail
- 刊名：Structure
- 出版年：6 May 2014
- 年：2014
- 卷：22
- 期：5
- 页码：719-730
- 全文大小：2764 K
文摘
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RNase AS strongly impacts mycobacterial virulence in vivo
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RNase AS specifically hydrolyzes poly(A) but not poly(C), poly(G), or poly(U)
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The crystal structure of RNase AS resembles that of RNase T from Escherichia coli
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The structures of RNase AS complexes reveal structural basis of enzyme specificity