Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition

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• 作者：Kartikeya Tiwari ; Ritesh Kumar ; Vikash Kumar Dubey ; ^{vdubey@iitg.ernet.in}
• 关键词：Leishmania donovani ; LdDHOase ; Anti-leishmanial ; Pyrimidine biosynthesis
• 刊名：Biochimie
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：131
• 期：Complete
• 页码：45-53
• 全文大小：1780 K
• 卷排序：131

文摘

L. donovani dihydroorotase inhibition by biotin sulfone and kaempferol was observed. Either of the two pathways of pyrimidine metabolism in combination or alone can support the parasitic growth. L. donovani dihydroorotase structure was determined using homology modeling.