A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes
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- 作者：Jona Freysdottira ; b ; c ; 1 ; jonaf@landspitali.is" class="auth_mail" title="E-mail the corresponding author ; Oddny T. Logadottira ; c ; d ; othl1@hi.is" class="auth_mail" title="E-mail the corresponding author ; Sesselja S. Omarsdottire ; sesselo@hi.is" class="auth_mail" title="E-mail the corresponding author ; Arnor Vikingssona ; arnor@landspitali.is" class="auth_mail" title="E-mail the corresponding author ; Ingibjorg Hardardottird ; 1 ; ih@hi.is" class="auth_mail" title="E-mail the corresponding author
- 关键词：DCs ; dendritic cells ; ELISA ; enzyme-linked immunosorbent assay ; IFN ; interferon ; IL ; interleukin ; LPS ; lipopolysaccharide ; MAP kinases ; mitogen-activated protein kinases ; MFI ; mean fluorescence intensity ; PI ; proportional index ; PMP ; 1-phenyl-3-methyl-5-pyrazolone ; RG ; rhamnogalacturonan ; SEM ; standard error of the mean ; SI ; secretion index ; TFA ; trifluoroacetic acid ; TLR ; toll-like receptor ; TNF ; tumor necrosis factor
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：143
- 期：Complete
- 页码：131-138
- 全文大小：1656 K
文摘
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A polysaccharide, Am-25-d, was isolated from Achillea millefolium.
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Am-25-d increased LPS-induced cytokine secretion by THP-1 monocytes.
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Am-25-d decreased LPS-induced phosphorylation/activation of Akt, ERK1/2 and NF-κB.
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Am-25-d may be of use as an immunoenhancer.