Ultrasound-assisted extraction of the three terpenoid indole alkaloids vindoline, catharanthine and vinblastine from Catharanthus roseus using ionic liquid aqueous solutions

详细信息    查看全文

• 作者：Lei  ; Yang¹ ; Han  ; Wang¹ ; Yuan-gang  ; Zu  ; ;   ; ^{zygnefu@163.com} ; Chunjian  ; Zhao ; Lin  ; Zhang ; Xiaoqiang  ; Chen ; Zhonghua  ; Zhang
• 关键词：Catharanthus roseus ; Ionic liquid-based ultrasonic-assisted extraction (ILUAE) ; Vindoline ; Catharanthine ; Vinblastine
• 刊名：Chemical Engineering Journal
• 出版年：2011
• 出版时间：15 August 2011
• 年：2011
• 卷：172
• 期：2-3
• 页码：705-712
• 全文大小：1396 K

文摘

Ionic liquid based, ultrasound-assisted extraction (ILUAE) was successfully applied to the extraction of 3 alkaloids, vindoline, catharanthine and vinblastine, from Catharanthus roseus. Twelve ionic liquids, with different cations and anions, were investigated in this work and [Amim]Br was selected as the optimal solvent. In addition, ultrasound extraction parameters, including soak time, solid¨Cliquid ratio, ultrasound power and time, and the number of extraction cycles, were optimized. ILUAE offered short extraction times (from 0.5 h to 4 h) and remarkable efficiency. The use of ionic liquids, in the ultrasound-assisted extraction of key chemicals from medicinal plants therefore shows great potential.