Mechanism of inhibition by chlorpromazine of the human pain threshold sodium channel, Na_v1.7

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• 作者：Su-Jin Lee^a ; Dong-Hyun Kim^a ; Sang June Hahn^b ; Stephen G. Waxman^c ; ^d ; ^e ; Jin-Sung Choi^a ; ^{jinsung.choi@catholic.ac.kr}
• 关键词：Chlorpromazine ; Voltage-gated sodium channel ; Nav1.7 ; Pain ; Calmodulin inhibitory peptide
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：1-7
• 全文大小：878 K
• 卷排序：639

文摘

CPZ blocks the hNav1.7 channel, independent of calmodulin. CPZ stabilizes inactivation states and decreases the availability of hNav1.7. CPZ blocks the hNav1.7 current in concentration-, state- and use-dependent manners.