Gestational and lactational exposure to di-isobutyl phthalate via diet in maternal mice decreases testosterone levels in male offspring

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• 作者：Xiaoyang Wang ; Nan Sheng ; Ruina Cui ; Hongxia Zhang ; Jianshe Wang ; Jiayin Dai ; ^{daijy@ioz.ac.cn}
• 关键词：Di-isobutyl phthalate (DiBP) ; Reproductive function ; Testosterone ; Phthalates
• 刊名：Chemosphere
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：172
• 期：Complete
• 页码：260-267
• 全文大小：692 K
• 卷排序：172

文摘

Maternal exposure to DiBP decreased offspring serum and testis testosterone levels. DiBP decreased expression of 3β-HSD and P450scc in PD21 pups and PD80 adults. Pre- and postnatal DiBP exposure impaired adult sperm concentration and motility.