Carnosic acid attenuates neuropathic pain in rat through the activation of spinal sirtuin1 and down-regulation of p66shc expression
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- 作者：Shuang-dong Chen ; Bin-bin Ji ; Yi-xiu Yan ; Xin He ; Kun-yuan Han ; Qin-xue Dai ; Ming-xiao Zhang ; Yun-chang Mo ; Jun-lu Wang ; wangjunlu973@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carnosic acid ; Neuropathic pain ; Sirtuin1 ; p66shc ; Spinal cord
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：95-102
- 全文大小：1063 K
文摘
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Carnosic acid can reduce mechanical allodynia and thermal hyperalgesia in neuropathic pain rats.
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Analgesic effect of carnosic acid is associated with Sirtuin1 activation and inhibition of p66shc in CCI rats.
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EX-527 reverses the anti-nociceptive effects of carnosic acid.