Re-examination of the rainbow trout (Oncorhynchus mykiss) immune response to flagellin: Yersinia ruckeri flagellin is a potent activator of acute phase proteins, anti-microbial peptides and pro-inflammatory cytokines in vitro

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• 作者：Eakapol Wangkahart^a ; ^b ; Callum Scott^a ; Christopher J. Secombes^a ; ^{c.secombes@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Tiehui Wang^a ; ^{t.h.wang@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Flagellin ; Yersinia ruckeri ; Rainbow trout ; Cytokine ; Acute phase protein ; Antimicrobial peptide
• 刊名：Developmental & Comparative Immunology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：75-87
• 全文大小：1633 K

文摘

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d="p0010">Yersinia ruckeri flagellin is a potent activator of fish pro-inflammatory cytokines.

dd><dt class="label">•dt><dd>

d="p0015">Y. ruckeri flagellin also activates acute phase proteins and antimicrobial peptides.

dd><dt class="label">•dt><dd>

d="p0020">Paralogues of trout inflammatory genes are differentially activated by flagellin.

dd><dt class="label">•dt><dd>

d="p0025">IFN-γ pretreament modulates flagellin-mediated inflammatory responses.

dd><dt class="label">•dt><dd>

d="p0030">IFN-γ pretreament promotes the expression of specific IL-12 isoforms in rainbow trout.

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