Re-examination of the rainbow trout (Oncorhynchus mykiss) immune response to flagellin: Yersinia ruckeri flagellin is a potent activator of acute phase proteins, anti-microbial peptides and pro-inflammatory cytokines in vitro
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- 作者：Eakapol Wangkaharta ; b ; Callum Scotta ; Christopher J. Secombesa ; c.secombes@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Tiehui Wanga ; t.h.wang@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flagellin ; Yersinia ruckeri ; Rainbow trout ; Cytokine ; Acute phase protein ; Antimicrobial peptide
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：75-87
- 全文大小：1633 K
文摘
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Yersinia ruckeri flagellin is a potent activator of fish pro-inflammatory cytokines.
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Y. ruckeri flagellin also activates acute phase proteins and antimicrobial peptides.
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Paralogues of trout inflammatory genes are differentially activated by flagellin.
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IFN-γ pretreament modulates flagellin-mediated inflammatory responses.
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IFN-γ pretreament promotes the expression of specific IL-12 isoforms in rainbow trout.