Aquaporin-4 deficiency facilitates fear memory extinction in the hippocampus through excessive activation of extrasynaptic GluN2B-containing NMDA receptors
详细信息 查看全文
- 作者：Xin Wua ; 1 ; Jie-Ting Zhanga ; 1 ; Di Lia ; Jun Zhoua ; Jun Yanga ; Hui-Ling Zhenga ; Jian-Guo Chena ; b ; c ; d ; e ; Fang Wanga ; b ; c ; d ; e ; wangfangtj0322@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AQP-4 ; Hippocampus ; NMDA receptor ; Fear memory extinction ; Long-term depression
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：124-134
- 全文大小：1805 K
文摘
- •
AQP-4 deficiency facilitates fear extinction.
- •
AQP-4 deficiency facilitates NMDAR-LTD in the CA3-CA1 pathway.
- •
Excessive activation of extrasynaptic GluN2B-NMDAR contributes to the changes in AQP-4 KO mice.