Calcinosis Cutis and Calciphylaxis

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• 作者：D. Jimé ; nez-Gallo ; ^{davidjimenezgallo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; L. Ossorio-Garcí ; a ; M. Linares-Barrios
• 关键词：Calcinosis cutis ; Cutaneous calcification ; Calciphylaxis ; Sodium thiosulfate
• 刊名：Actas Dermo-Sifiliográficas (English Edition)
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：106
• 期：10
• 页码：785-794
• 全文大小：2784 K

文摘

Calcinosis cutis (CC) is defined as the deposition of calcium salts in the skin. The condition is divided into 5 types: calciphylaxis and dystrophic, metastatic, idiopathic, and iatrogenic CC. Dystrophic CC is the most common form and usually occurs in association with autoimmune diseases. CC can be treated surgically or with the use of drugs such as diltiazem, bisphosphonates, warfarin, ceftriaxone, probenecid, minocycline, or aluminum hydroxide. Calciphylaxis is defined as calcification of the media of small- and medium-sized blood vessels in the dermis and subcutaneous tissue. Clinically, calciphylaxis causes livedo racemosa, which progresses to retiform purpura and skin necrosis. First-line treatment is with sodium thiosulfate. We present a review of the calcifying disorders of the skin, focusing on their diagnosis and treatment.