Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression

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• 作者：Henrik N. Klø ; verpris¹ ; ² ; ^{henrik.kloverpris@k-rith.org" class="auth_mail" title="E-mail the corresponding author} ; Samuel W. Kazer³ ; ⁴ ; ⁵ ; ⁶ ; Jenny Mjö ; sberg⁷ ; Jenniffer M. Mabuka¹ ; Amanda Wellmann¹ ; Zaza Ndhlovu⁸ ; Marisa C. Yadon¹ ; Shepherd Nhamoyebonde¹ ; Maximilian Muenchhoff⁸ ; ⁹ ; Yannick Simoni¹⁰ ; Frank Andersson¹¹ ; Warren Kuhn¹² ; Nigel Garrett¹³ ; ¹⁴ ; Wendy A. Burgers¹⁵ ; Philomena Kamya³ ; ⁸ ; Karyn Pretorius⁸ ; Krista Dong³ ; Amber Moodley³ ; Evan W. Newell¹⁰ ; Victoria Kasprowicz¹ ; Salim S. Abdool Karim¹⁴ ; ¹⁶ ; Philip Goulder⁸ ; ⁹ ; Alex K. Shalek³ ; ⁴ ; ⁵ ; ⁶ ; ¹⁷ ; Bruce D. Walker³ ; ⁸ ; ¹⁸ ; Thumbi Ndung&rsquo ; u¹ ; ³ ; ⁸ ; ¹⁹ ; Alasdair Leslie¹ ; ³
• 关键词：innate lymphoid cells ; HIV-1 infection
• 刊名：Immunity
• 出版年：2016
• 出版时间：16 February 2016
• 年：2016
• 卷：44
• 期：2
• 页码：391-405
• 全文大小：4737 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">ILCs are depleted from the blood during early acute HIV-1 infection

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d="p0015">Antiretroviral therapy initiated in acute, but not chronic, infection preserves ILCs

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d="p0020">RNA sequencing of ILCs during acute infection implicates apoptosis in their depletion

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d="p0025">Remaining ILCs in chronic disease are activated but do not migrate to tissue sites

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