Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracelullar striatal dopamine

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• 作者：Wassilios Meissner ; Paula Ravenscroft ; René ; Reese ; Daniel Harnack ; Rudolf Morgenstern ; Andreas Kupsch ; Henrik Klitgaard ; Bernard Bioulac ; Christian E. Gross ; Erwan Bezard and Thomas Boraud
• 关键词：Dyskinesia ; Local field potential ; Oscillation ; Microdialysis ; Parkinson's disease
• 刊名：Neurobiology of Disease
• 出版年：2006
• 出版时间：June 2006
• 年：2006
• 卷：22
• 期：3
• 页码：586-598
• 全文大小：564 K

文摘

Since electrophysiological correlates of l-dopa-induced dyskinesia (LID) are almost unknown, changes of striatal dopamine (DA) transmission and electrophysiological activity of the substantia nigra pars reticulata (SNr) were recorded before and after acute l-dopa administration in sham-operated and 6-hydroxydopamine (6-OHDA)-lesioned rats that were previously treated with vehicle or l-dopa for 10 days. Abnormal involuntary movements occurred only in the l-dopa-primed 6-OHDA-lesioned rats that showed after acute l-dopa administration a decrease in firing rate, the highest local field potential power in the theta/alpha band, a consequent oscillatory activity in the same frequency band at the single neuron level and an excessive increase in striatal DA release associated with the lowest level of DA metabolism. These results suggest that increased synchronised afferent activity may drive SNr oscillations in the same frequency band and is associated with abnormal involuntary movements, further suggesting the potential use of desynchronising drugs for managing LID in Parkinson's disease.