High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster

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• 作者：René ; Reese ; Giselle Charron ; Agnè ; s Nadjar ; Incarnation Aubert ; Marie-Laure Thiolat ; Melanie Hamann ; Angelika Richter ; Erwan Bezard ; Wassilios G Meissner
• 关键词：c-Fos ; Cytochrome oxidase ; Deep brain stimulation ; Internal pallidum
• 刊名：Neurobiology of Disease
• 出版年：2009
• 出版时间：September 2009
• 年：2009
• 卷：35
• 期：3
• 页码：399-405
• 全文大小：929 K

文摘

High frequency stimulation (HFS) of the internal pallidum is effective for the treatment of dystonia. Only few studies have investigated the effects of stimulation on the activity of the cortex-basal ganglia network. We here assess within this network the effect of entopeduncular nucleus (EP) HFS on the expression of c-Fos and cytochrome oxidase subunit I (COI) in the dt^sz-hamster, a well-characterized model of paroxysmal dystonia. In dt^sz-hamsters, we identified abnormal activity in motor cortex, basal ganglia and thalamus. These structures have already been linked to the pathophysiology of human dystonia. EP-HFS (i) increased striatal c-Fos expression in controls and dystonic hamsters and (ii) reduced thalamic c-Fos expression in dt^sz-hamsters. EP-HFS had no effect on COI expression. The present results suggest that EP-HFS induces a new network activity state which may improve information processing and finally reduces the severity of dystonic attacks in dt^sz-hamsters.