Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins
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- 作者：Keiko Matsuda1 ; 2 ; 7 ; Timotheus Budisantoso1 ; 2 ; 7 ; Nikolaos Mitakidis3 ; Yuki Sugaya4 ; Eriko Miura1 ; 2 ; Wataru Kakegawa1 ; 2 ; Miwako Yamasaki2 ; 5 ; Kohtarou Konno2 ; 5 ; Motokazu Uchigashima2 ; 5 ; Manabu Abe2 ; 6 ; Izumi Watanabe2 ; 6 ; Masanobu Kano4 ; Masahiko Watanabe2 ; 5 ; Kenji Sakimura2 ; 6 ; A. Radu Aricescu3 ; 8 ; radu@strubi.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Michisuke Yuzaki1 ; 2 ; 8 ; myuzaki@a5.keio.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：18 May 2016
- 年：2016
- 卷：90
- 期：4
- 页码：752-767
- 全文大小：6404 K
文摘
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C1ql2 and C1ql3 from mossy fibers (MFs) locate at MF-CA3 synapses in hippocampus
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C1ql2/3 directly bind to the GluK2 and GluK4 kainate receptors (KARs)
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Neurexin3 binds C1ql2/3 via the splice site 5 sequence and accumulates KARs
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C1ql2/3 serve as master regulators of postsynaptic KAR complexes in CA3 neurons