ZrCl₄/Hantzsch 1,4-dihydropyridine as a new and efficient reagent combination for the direct reductive amination of aldehydes and ketones with weakly basic amines

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• 作者：Zhen Gang Liu ; Nan Li ; Li Yang ; Zhong Li Liu ; Wei Yu
• 关键词：Zirconium tetrachloride ; Hantzsch 1 ; 4-dihydropyridine ; Reductive amination
• 刊名：Chinese Chemical Letters
• 出版年：2007
• 出版时间：April 2007
• 年：2007
• 卷：18
• 期：4
• 页码：458-460
• 全文大小：123 K

文摘

ZrCl₄/Hantzsch 1,4-dihydropyridine is a mild and highly efficient reagent combination for the direct reductive amination. Weakly basic amines such as anilines substituted by electron-withdrawing group and heteroaromatic amines can be reductively alkylated with electron rich aldehydes and ketones under mild conditions to form the secondary amines in excellent yields.