Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function
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- 作者：Antonella Papa1 ; Lixin Wan2 ; Massimo Bonora3 ; Leonardo Salmena1 ; 6 ; Min Sup Song1 ; 7 ; Robin M. Hobbs1 ; 8 ; Andrea Lunardi1 ; Kaitlyn Webster1 ; Christopher Ng1 ; Ryan H. Newton4 ; 9 ; Nicholas Knoblauch2 ; Jlenia Guarnerio1 ; Keisuke Ito1 ; 10 ; Laurence A. Turka4 ; 9 ; Andy H. Beck2 ; Paolo Pinton3 ; Roderick T. Bronson5 ; Wenyi Wei2 ; Pier Paolo Pandolfi1 ; ppandolf@bidmc.harvard.edu" class="auth_mail
- 刊名：Cell
- 出版年：24 April 2014
- 年：2014
- 卷：157
- 期：3
- 页码：595-610
- 全文大小：4395 K
文摘
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PTEN exists in an active, unphosphorylated dimeric conformation
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PTEN missense mutations exert dominant-negative effects over the wild-type protein
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Pten mutations elicit Akt hyperactivation and augmented tumorigenesis in the mouse
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Mutant PTEN associates with increased AKT phosphorylation in human cancer