Inhibition of ERK/MAPK suppresses avian leukosis virus subgroup A and B replication

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• 作者：Manman Dai^a ; ^c ; ^d ; ^e ; ¹ ; ^{daimanman1229@163.com} ; Min Feng^b ; ¹ ; ^{hunanfengmin@163.com} ; Ming Liao^a ; ^c ; ^d ; ^e ; ^{mliao@scau.edu.cn} ; Weisheng Cao^a ; ^c ; ^d ; ^e ; ^{caoweish@scau.edu.cn}
• 关键词：ALV-A ; ALV-B ; ERK/MAPK pathway ; Virus replication
• 刊名：Microbial Pathogenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：29-35
• 全文大小：1125 K
• 卷排序：102

文摘

We successfully constructed and recovered a recombinant form of ALV-A strain GD13-1. This study firstly reported that ALV subgroups J, A or B all triggered ERK2 activation in primary CEF cells. PD98059 markedly suppressed ALV replication which may represent novel drug targets for preventive strategies.