Plasmonic ZnO nanorods/Au substrates for protein microarrays with high sensitivity and broad dynamic range
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- 作者：Chang LiuaAuthor Vitae ; Fanling MengaAuthor Vitae ; Weitao Zhenga ; wtzheng@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Tianyu XueaAuthor Vitae ; Zhao JinaAuthor Vitae ; Zhenxin Wangb ; wangzx@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Xiaoqiang Cuia ; xqcui@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：ZnO nanorods ; Plasmonic ; Fluorescence enhancement ; Protein microarray ; Immunoassay ; Biomarker detection
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：231-236
- 全文大小：1540 K
文摘
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The ZnO-NRs/Au substrate is a promising candidate for developing mass-manufactured, low cost, sensitive, and high-throughput protein microarray platforms.
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The large surface area of the ZnO-NRs nanoarrays and the plasmonic coupling effects of the Au nanofilm result in a significant fluorescence signal enhancement.
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The cancer biomarker CEA is detected in a broad dynamic range of 100 pg mL−1 to 100 μg mL−1 with a limit of detection of 27 pg mL−1.