Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway

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• 作者：Lu Liu ; Weiwei Huang ; Jianhong Wang ; Huiling Song ; Juan Cen ; ^{cenjuan@henu.edu.cn} ; Biansheng Ji ; ^{jibiansheng2005@126.com}
• 关键词：BME ; Oxygen-glucose deprivation ; PC12 cells ; Hormetic effect ; Nrf2
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：262
• 期：Complete
• 页码：1-11
• 全文大小：3023 K
• 卷排序：262

文摘

BME showed biphasic dose response to OGD-induced injury in PC12 cells. BME activated ERK and Akt under both OGD and normal condition. BME depressed OGD-induced mitochondrial apoptosis via activation of Nrf2/HO-1.