Metabolic syndrome and its individual components with mortality among patients with coronary heart disease

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• 作者：Qian Chen^a ; ^b ; ¹ ; Yuan Zhang^c ; ¹ ; Ding Ding^a ; ¹ ; Dan Li^a ; ¹ ; Min Xia^a ; ¹ ; Xinrui Li^a ; ¹ ; Yunou Yang^a ; ¹ ; Qing Li^a ; ¹ ; Gang Hu^b ; ¹ ; ^{gang.hu@pbrc.edu" class="auth_mail" title="E-mail the corresponding author} ; Wenhua Ling^a ; ¹ ; ^{lingwh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Coronary heart disease ; Metabolic syndrome ; All-cause mortality ; Cardiovascular mortality ; Cohort study
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：224
• 期：Complete
• 页码：8-14
• 全文大小：309 K

文摘

The metabolic syndrome (MetS) and its metabolic risk factors appear to promote the development of atherosclerotic cardiovascular disease. The aim of this study was to examine the association of MetS and its individual components with all-cause and cardiovascular mortality among patients with coronary heart disease (CHD).

Methods

We performed a prospective, hospital-based cohort among 3599 CHD patients in China. Cox proportional hazards regression models were used to estimate the association of MetS and its components at baseline with risk of mortality.

Results

During a mean follow-up period of 4.9 years, 308 deaths were identified, 200 of which were due to cardiovascular disease. Compared with patients without MetS, patients with MetS according to the AHA/NHLBI statement had a 1.26-fold higher risk (95% CI, 1.01–1.59) of all-cause mortality and a 1.41-fold higher risk (1.06–1.87) of cardiovascular mortality. Patients with increasing numbers of components of MetS had a gradually increased risk for all-cause and cardiovascular mortality (P < 0.05). When each component of MetS was considered as a dichotomized variable separately, only low high-density lipoprotein cholesterol (HDL-C) and elevated fasting blood glucose (FBG) were associated with all-cause and cardiovascular mortality. After using restricted cubic splines, we found a U-shaped association of HDL-C, body mass index and blood pressure, a positive association of FBG, and no association of triglycerides with the risks of all-cause and cardiovascular mortality.

Conclusions

MetS is a risk factor for all-cause and cardiovascular mortality among CHD patients. It is very important to control metabolic components in a reasonable control range.