MicroRNA-376c suppresses non-small-cell lung cancer cell growth and invasion by targeting LRH-1-mediated Wnt signaling pathway
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- 作者：Wenjun Jiang ; wenjunjiang123@163.com" class="auth_mail" title="E-mail the corresponding author ; Ye Tian ; Shu Jiang ; Siyang Liu ; Xitong Zhao ; Dali Tian
- 关键词：Liver receptor homolog-1 ; Non-small-cell lung cancer ; miR-376c ; Wnt
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：980-986
- 全文大小：2267 K
文摘
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LRH-1 is highly overexpressed in NSCLC cell lines.
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Suppression of LRH-1 inhibits NSCLC cell growth and invasion.
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miR-376c targets and regulates LRH-1.
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miR-376c regulates LRH-1/Wnt signaling pathway.